Does Prednisone Increase Blood Pressure? Why and How Does Prednisone Raise Blood Pressure? How Much Does Prednisone Raise Blood Pressure, and How Long Does It Take? Other Common Side Effects of Prednisone. Swollen hands, feet, and ankles (fluid retention) High blood sugar (Hyperglycemia) Frequent indigestion (Gastrointestinal discomfort)
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