Acarbose vs metformin

Recent evidence suggested that acarbose might be similar to metformin in glucose-lowering efficacy and cardiovascular risk reduction. Therefore, international guidelines have suggested the use of acarbose as alternative first-line antidiabetic therapy. To compare the cardiovascular outcomes in the first-line users of acarbose vs metformin.

Acarbose Metformin is a combination of two antidiabetic medicines: Acarbose and metformin. Acarbose works by slowing down the breakdown of complex sugars into simpler sugars. This reduces the post-meal rise in blood sugar. Metformin lowers the production and absorption of sugar in your body and allows better use of existing insulin.

by J Hoffmann 2024 Cited by 218Relative postprandial insulin increase was 1.90 with placebo, 1.09 with acarbose, and 1.03 with metformin. Comparisons: acarbose versus placebo and metformin

The C max of glucose after an oral sucrose load was reduced on average by about 17%, 22%, and 21% after treatment with acarbose/metformin FDC, acarbose/metformin LC, and acarbose alone, whereas no effect was seen for metformin alone. 20 There was a minor reduction in AUC (0-4h) for PPG by about 3% after intake of the acarbose-containing drugs

How Acarbose Metformin worksAcarbose Metformin is a combination of two antidiabetic medicines: Acarbose and metformin. Acarbose works by slowing down

Compared with repaglinide-metformin, acarbose-metformin was more effective in GV control at 12 weeks post commencement of new medications (p 0.05 respectively), demonstrated by the smaller MAGE, SDBG, CVBG, PPGE, and LAGE in the acarbose-metformin combination group than in the repaglinide-metformin combination group (p 0.05 respectively

Acarbose vs metformin for new-onset type 2 diabetes Lancet Diabetes Endocrinol. 2024 Feb;2(2):104. doi: 10.1016/S (13) .

The difference between pre- and posttreatment levels of the 2-h PPBG level in both arms of the study were statistically significant ( -acarbose, 5.3 0.4 vs. ff-metformin, 2.9 0.3) (P 0.05). Specific drug-associated side effects were observed in 12 patients on acarbose and 3 patients on metformin.

Gliclazide ; Gliclazide MR ; Metformin ; Acarbose (Glucobay) ; Sitagliptin (DPP4 inhibitor)