Phenytoin vs fosphenytoin

Phenytoin vs Fosphenytoin. The efficacy of phenytoin and fosphenytoin for time to seizure cessation are comparable, however there are theoretical reasons why fosphenytoin might be preferred: Phenytoin and fosphenytoin have sodium channel blockade effects, which is similar to the mechanism of action of certain toxidromes such as TCA and cocaine

Phenytoin and fosphenytoin are the same active medication. For these reasons fosphenytoin is the preferred second line agent for treatment of

Phenytoin vs Fosphenytoin. The efficacy of phenytoin and fosphenytoin for time to seizure cessation are comparable, however there are theoretical reasons why

by M Madhiyazhagan 2024of seizure with phenytoin compared to the fosphenytoin arm (17.7% vs. Favorable STESS (≤2) was higher with phenytoin compared to fosphenytoin

Dose equivalence and conversion for fosphenytoin sodium Doses are expressed as phenytoin sodium equivalent (PE); fosphenytoin sodium 1.5 mg ≡ phenytoin sodium

They reported that levetiracetam was not superior to phenytoin. Comparing levetiracetam vs. fosphenytoin vs. valproate groups – no

This results in slow and erratic absorption (7, 10). Like phenytoin, fosphenytoin binds extensively to albumin. It displaces any lingering phenytoin from plasma protein bindBUMC PROCEEDINGS 2024; JULY 2024 PHENYTOIN VS FOSPHENYTOIN ing sites, increasing up to 30% the unbound phenytoin fraction available for antiepileptic activity.

vs 11% of IM placebo-treated patients hypoalbuminemia, fosphenytoin clearance to phenytoin may be increased without a similar increase in phenytoin clearance.

Fosphenytoin is a prodrug. It is converted rapidly (half-life15 minutes) to phenytoin. Fosphenytoin is less alkaline than phenytoin and can be