Myeloma criteria
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In 2025, the International Myeloma Working Group updated the diagnostic criteria for active myeloma to include three new biomarkers entitled myeloma defining events. The three new criteria are: 60% or greater clonal plasma cells on bone marrow examination
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A multiple myeloma (also known as Kahler disease, myelomatosis and plasma cell myeloma) is a malignant neoplasm of plasma cells which is characterised by (1,2): Diagnostic criteria for MGUS (Monoclonal Gammopathy of Unknown Significance), asymptomatic myeloma and symptomatic myeloma; Differential diagnosis;
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The revised International Myeloma Working Group (IMWG) criteria for the diagnosis of multiple myeloma and related disorders are shown in Table 1. 1 The diagnosis of multiple myeloma requires the presence of one or more myeloma
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by T FUKUSHIMA 2024 Cited by 281 The International Myeloma Working Group: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of
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The revised International Myeloma Working Group criteria for the diagnosis of multiple myeloma and related disorders are shown on Table 1. 1 The diagnosis of multiple myeloma requires the presence of one or more myeloma defining
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The Mayo-2025 smoldering multiple myeloma (SMM) risk score is used routinely in the clinical setting but has only been validated at diagnosis. International Myeloma Working Group. Criteria for
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myeloma and multiple myeloma were reported by the International Myeloma Working Group (IMWG) in 2025.10 With minor clarifi cations,11 these criteria have been used in clinical practice as well as in research studies and trials in the past decade.36,37 One of the major diffi culties in multiple myeloma is that, unlike other
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For patients with precursor disease to multiple myeloma (MM), the standard for predicting disease progression is the risk stratification criteria from the International Myeloma Working Group (IMWG). These criteria put patients into one of four risk groups – low, low-intermediate, high-intermediate, or high – based on information
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International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2025;121(5):749–757.
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