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Author: Admin | 2025-04-28
Should not use this medicine if you are allergic to bupropion or naltrexone, or if you have:untreated or uncontrolled high blood pressure;an eating disorder (anorexia or bulimia);a history of seizures;opioid addiction or withdrawal (or if you take methadone or buprenorphine);if you take other forms of bupropion (Wellbutrin, Aplenzin, Budeprion, Forfivo, Zyban, and others); orif you have suddenly stopped using alcohol, seizure medication, or a sedative such as Xanax, Valium, Fiorinal, Klonopin, and others).Do not use opioid medication for a minimum of 7 to 10 days before starting bupropion and naltrexone.Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropion and naltrexone. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.Tell your doctor if you have ever had:depression, bipolar disorder, or mental illness;suicidal thoughts or actions;a head injury;a tumor or infection in your brain or spinal cord;diabetes or low blood sugar;low sodium levels;liver or kidney disease;heart disease, high blood pressure, heart attack, or stroke; ordrug addiction, or if you normally drink a lot of alcohol.Some young people have thoughts about suicide when first taking bupropion. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.You should not breastfeed while using this medicine.This medicine is not approved for use by anyone younger than 18 years old.How should I take bupropion and naltrexone?Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.Swallow the tablet whole and do not crush, chew, or break it.Do not take more than 2 tablets at once.Do not take bupropion and naltrexone with a high-fat meal, or you may be more likely to have a seizure.If you need to use opioid medicine for any reason (such as pain, surgery, or treatment for drug addiction) you may need to stop taking bupropion and naltrexone for a short time. Follow your doctor's dosing instructions very carefully.This medicine may affect a drug-screening urine test and you may have false results. Tell the laboratory staff that you use bupropion and naltrexone.Store at room temperature away from moisture and heat.If you have not lost at least 5% of your starting weight after 16 weeks of treatment, this medicine may not be right for you.Bupropion and naltrexone dosing informationUsual Adult Dose for Weight Loss:Each extended-release tablet contains naltrexone 8 mg/bupropion 90 mg: Initial dose: -Week 1: One tablet orally once a day in the morning -Week 2: One tablet orally 2 times a day (morning and evening) -Week 3: Two tablets orally in the morning and 1 tablet orally in the evening -Week 4: Two tablets orally 2 times a day (morning and evening) Maintenance dose: 2 tablets orally 2 times a day (morning and evening) Maximum dose: 4 tablets/day (naltrexone 32 mg/bupropion 360 mg) Comments:-Therapy should be discontinued if a patient has not lost at least 5%
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