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Author: Admin | 2025-04-28
Tabletswere not taken with water: choking, gagging, tablet stuck in throat and dysphagia (see PATIENT INFORMATION). Drug Interactions for LevoxylMany drugs affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis,secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic responseto LEVOXYL. In addition, thyroid hormones and thyroid status have varied effects on thepharmacokinetics and action of other drugs. A listing of drug-thyroidal axis interactions is contained inTable 2.The list of drug-thyroidal axis interactions in Table 2 may not be comprehensive due to the introductionof new drugs that interact with the thyroidal axis or the discovery of previously unknown interactions.The prescriber should be aware of this fact and should consult appropriate reference sources. (e.g.,package inserts of newly approved drugs, medical literature) for additional information if a drug-druginteraction with levothyroxine is suspected.Table 2: Drug - Thyroidal Axis Interactions Drug or Drug Class Effect Drugs that may reduce TSH secretion -the reduction is not sustained; therefore, hypothyroidism does not occur Dopamine / Dopamine Agonists Glucocorticoids Octreotide Use of these agents may result in a transient reduction in TSH secretion when administered at the following doses: Dopamine (≥1 mcg/kg/min); Glucocorticoids (hydrocortisone ≥100 mg/day or equivalent); Octreotide (>100 mcg/day). Drugs that alter thyroid hormone secretion Drugs that may decrease thyroid hormone secretion, which may result in hypothyroidism Aminoglutethimide Amiodarone Iodide (including iodine-containing Radiographic contrast agents) Lithium Methimazole Propylthiouracil (PTU) Sulfonamides Tolbutamide Long-term lithium therapy can result in goiter in up to 50% of patients, and either subclinical or overt hypothyroidism, each in
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