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Author: Admin | 2025-04-28
Failure†Oral25–50 mg once daily initially; target dosage of 150 mg daily.Special PopulationsHepatic ImpairmentMild to moderate hepatic impairment: initiate at 25 mg once daily.Severe hepatic impairment: not studied.Renal ImpairmentNo dosage adjustment necessary for adults with renal impairment unless volume depleted.Not recommended for use in pediatric patients with eGFR 2.Geriatric PatientsNo dosage recommendations at this time.Cautions for Losartan PotassiumContraindicationsKnown hypersensitivity to losartan or any ingredient in the formulation.Concomitant therapy with aliskiren in patients with diabetes mellitus.Warnings/PrecautionsWarningsFetal/Neonatal Morbidity and MortalityRisk of fetal harm when administered to a pregnant woman (See Boxed Warning). Possible reduction in fetal renal function and increase in fetal and neonatal morbidity and mortality when drugs that act on the renin-angiotensin system (RAS) are used during the second and third trimesters of pregnancy. Oligohydramnios caused by drugs that act on the RAS can result in fetal lung hypoplasia, skeletal deformations (including skull hypoplasia), anuria, hypotension, renal failure, and death. Discontinue losartan immediately when pregnancy detected. If there is no appropriate alternative therapy, apprise the mother of the potential risk to the fetus. If losartan is taken during pregnancy, perform serial ultrasound examinations to assess intra-amniotic environment; if oligohydramnios observed, discontinue losartan, unless it is considered life-saving for the mother. Oligohydramnios may not appear until after irreversible injury to the fetus. Closely observe neonates exposed to losartan in utero for signs of hypotension, oliguria, and hyperkalemia. If oliguria or hypotension occurs, support BP and renal perfusion. Exchange transfusions or dialysis may be required.Other Warnings and PrecautionsHypotension in Volume- or Salt-Depleted PatientsPossible symptomatic hypotension, particularly in volume- and/or salt-depleted patients (e.g., those treated with diuretics). Correct volume or salt depletion prior to losartan administration.Renal Function DeteriorationChanges in renal function, including acute renal failure, possible. Patients with renal artery stenosis, CKD, severe congestive heart failure, or volume depletion at higher risk of acute
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