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Author: Admin | 2025-04-28
May resurface, whereas when a low-dose user discontinues treatment – more manageable acid reflux may resurface.The resurgence of a severe acid reflux condition might exacerbate withdrawal symptoms for the former high-dose user – whereas symptom exacerbation might be less significant for the low-dose user. Moreover, if physiologic adaptations are incurred from omeprazole administration – then the adaptations might be more significant among high-dose users.If more significant physiologic adaptations are incurred by high-dose users (than low-dose users), then there might be a more significant rebound effect (e.g. rebound acid hypersecretion) after discontinuation. For this reason, one might expect withdrawal symptoms to be more severe among high-dose users – relative to low-dose users.Rate of omeprazole discontinuationAccording to Haastrup et al. (2014), tapering appears to be the most effective strategy for abrupt discontinuation of proton-pump inhibitors like omeprazole, whereas abrupt or “cold turkey” discontinuation is more challenging. It is thought that quitting cold turkey may increase likelihood of and/or severity of hypergastrinemia and rebound acid hypersecretion in withdrawal – especially among long-term users.Most speculate that gradually tapering off of omeprazole guides the user’s physiology closer to homeostasis before complete cessation – allowing for quicker recovery and fewer discontinuation symptoms. Conversely, it is thought that sudden discontinuation of omeprazole after long-term and/or high-dose use leaves the physiology in an omeprazole-adapted state (further from homeostasis) whereby withdrawal symptoms are more severe and longer-lasting.Although some evidence presented by Reimer et al. (2009) suggests that there may be no difference in withdrawal symptom severity among those who discontinue proton-pump inhibitors abruptly versus those who taper, anecdotal accounts have reported fewer discontinuation symptoms after a gradual taper. While the rate of omeprazole discontinuation may not influence the severity of everyone’s withdrawal symptoms – it might be a significant influencer of withdrawal severity for a subset of former users.Source: https://www.ncbi.nlm.nih.gov/pubmed/25192903Source: https://www.ncbi.nlm.nih.gov/pubmed/19362552Use of substances while withdrawing from omeprazoleIf you’re using substances (e.g. medications, supplements, etc.) while withdrawing from omeprazole, you may be at lower risk of experiencing severe withdrawal symptoms than if you weren’t using any substances. Obviously if you discontinue omeprazole and immediately transition to a different proton-pump inhibitor OR an acid reducing agent (e.g. an H2 antagonist) – you probably won’t notice any withdrawal symptoms because these substances will exert similar effects as omeprazole.Moreover, even if you’re using substances that are unrelated to omeprazole (and that have no substantial effect on stomach acid production) such as: probiotics, anxiolytics,
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